Endocrine Abstracts

Background: There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves’ disease (GD). The objectives of this study were to assess the natural course of individuals with SH due to GD over a prolonged period. We also investigated the factors contributing to the progression or remission in these patients.Methods: A prospective analysis of patients with SH due to GD between 2007 and 2013 who had at least ...

Objective: To determine whether people with an incidentally discovered adrenal mass are investigated according to regional and global standards (AACE guidelines); to determine the frequency of autonomous endocrine function.Methods: We did a retrospective analysis of clinical, pathology, and radiology records from January 2007 to December 2011. Patients were included if they were seen in the outpatient clinic for evaluation of an adrenal mass >1 cm in...

Case report: A 65-year-old fisherman presented with altered mental status, agitation, generalised oedema, dyspnoea, liver impairment and severe persistent hypokalaemia (2.2 mmol/l). History: COPD, IPF (on steroids since May 2012), ex-smoker. Physical examination: deeply tanned, Cushingoid facies, severe proximal myopathy. Medications prior to admission: prednisolone 40 mg OD, furosemide 40 mg OD, inhalers, and lansoprazole. In a view of clinical and biochemical features of ste...

Introduction: We submit a rare presentation of pheaochromocytoma in pregnanacy, diagnosed just before delivery, posing complex management difficulties.Case presentationA 24-year-old primipara had headache, hypertension and visual disturbance but without any palpitations or diaphoresis. Her headache was persistent during pregnancy. Investigations at 39 weeks of gestation showed normal plasma Normetadrenaline at 885.0 (120–1180)...

Introduction: Hypothalamic–pituitary sarcoidosis is uncommon and affects <10% of patients with neurosarcoidosis. It presents a diagnostic challenge. We present a case of isolated central hypoadrenalism presenting as the sole manifestation of neurosarcoidosis.Case history: A 76-year-old man with recently diagnosed primary hypothyroidism presented with weight loss, increasing lethargy and fatigue. Physical exam revealed inguinal lymhadenopathy. St...

Postoperative hypocalcaemia is usually transient; we present a case report of persistent symptomatic hypocalcaemia following elective thyroid surgery; its challenging pharmaceutical management including the successful use of a novel therapeutic agent. A 56 yr old woman with known type 2 diabetes, morbid obesity (treated with gastric band), and benign intracranial hypertension underwent total thyroidectomy for a multi-nodular goitre, following which she became symptomatic with ...

Introduction: TKI are an emerging group of anti-growth factor agents used in the treatment of solid cancers. Treatment is associated with thyroid dysfunction. Sunitinib is licensed for the treatment of metastatic RCC. Our objective was to determine the incidence of Sunitinib induced thyroid dysfunction and its management in patients with renal RCC.Methods: Retrospective case note analysis of patients started on Sunitinib for metastatic RCC between Januar...

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...